Pair Name	Genipin, Everolimus
Disease Info	[ICD-11: 2C10.Z]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Proliferation
Gene Regulation	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	UCP2	hsa7351
	Up-regulation	Expression	MTOR	hsa2475
	Up-regulation	Expression	AKT1	hsa207
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	PaCa-44	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_7087
	PaCa-3	Pancreatic carcinoma	Homo sapiens (Human)	CVCL_4011
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
	MIA PaCa-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0428
	T3M-4	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_4056
In Vivo Model	PaCa44 cells (1×10⁶ cells/mice) were s.c. injected into the dorsal flank of six nude female mice for each condition (5 weeks of age; Charles River Laboratories, Inc.).
Result	These results reveal novel mechanisms through which UCP2 promotes cancer cell proliferation and support the combined inhibition of UCP2 and of Akt/mTOR pathway as a novel therapeutic strategy in the treatment of pancreatic adenocarcinoma.